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Research Progress of Microemulsion-based Drug Delivery Systems Lü Fengfeng, Liu Shaojie, Liu Jie, Li Ganzuo, Zheng Liqiang* Abstract The systems of microemulsions are currently of interest to
the pharmaceutical scientist because of their considerable potential to act as drug
delivery vehicles by incorporating a wide range of drugs. The microemulsion-based drug
delivery systems are often used to control or delay the release of the entrapped drugs.
This paper gives an overview of the formation, phase behaviour and characterization of
microemulsions. The factors that influence the release of the incorporated drugs and the
importance of the nonionic surfactants, such as Span and Tween are also discussed. 微乳液作为药物载体研究进展 吕锋锋 刘少杰 刘 杰 李干佐 郑利强*(胶体与界面化学教育部重点实验室 (山东大学) 济南 250100) 摘要 总结了微乳液型药物载体在药物缓释和控释方面的研究背景、现状及方法；介绍了微乳液型药物载体的组分选择原则；讨论了影响微乳液型药物载体中药物释放的因素以及斯潘，吐温系列的表面活性剂在药物载体的研究中的重要性。关键词 微乳液 药物载体 药物缓释 研究进展 吕锋锋 女，24岁，硕士生，现从事表面活性剂物理化学的研究。*联系人，E-mail: lqzheng@sdu.edu.cn国家自然科学基金(20243005)、贵州省长基金黔科教办(2001)6号资助项目 2003-07-09收稿，2003-10-10接受 |