Study of Preparation of Polybutylcyanoacrylate Nanocapsules

Li Sai, Qian Zhiyong, Zou Yaobang, Zhang Hailian, Liu Xiaobo*
(Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041)

Abstract Polybutylcyanoacrylate(PBCA) nanocapsules were prepared by modified interfacial polymerization method. The influences of stirring rate, concentration of ethanol, pH value and solvent on nanocapsules diameter and regularity were investigated. The diameter of PBCA nanocapsules ranged from 100 to 200nm, and the wall thickness of PBCA nanocapsules was about 150nm.
Key words Nanocapsules, Polybutylcyanoacrylate, Interfacial polymerization

　

聚a-氰基丙烯酸丁酯纳米微囊的制备

李 赛 钱志勇 邹耀邦 张海连 刘孝波*
(中国科学院成都有机化学研究所 成都 610041)

摘要 通过改进的界面聚合方法合成了聚a-氰基丙烯酸丁酯纳米微囊，重点研究了搅拌速率、pH、乙醇浓度、溶剂等聚合条件对纳米微囊的粒径分布及规整性的影响。获得了平均粒径为150nm、壁厚规整的纳米微囊。
关键词 纳米微囊 聚a-氰基丙烯酸丁酯 界面聚合

李赛 男，26岁，博士生，现从事纳米粒子药物靶向缓释制剂的研究。*联系人
中国科学院院长特别基金、四川省杰出青年基金资助项目
2002-07-01收稿，2002-10-28修回

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