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Materials and Fabricating Methods of Microcapsules for Cell Transplantation Xue Weiming, Yu Weiting, Wang Wei, Liu Xiudong, Ma Xiaojun* Abstract Immunological rejection is the key problem of cell
transplantation. Based on the permselective property of microcapsule membrane,
encapsulated cells can be immuno-protected. The normal physiological state and function
expression of cells can be maintained so as to realize allo-orxeno-transplantation. In
this paper, the latest progress relevant to materials and fabricating methods for cell
microencapsulation was reviewed. The physicochemical characteristics and applications of
alginate, polylysine, chitosan and agarose as well as fabricating methods such as
polyelectrolyte complexation, interfacial phase inversion and conformal coating techniques
were mainly concerned.
细胞移植用微胶囊的制备材料与制备方法 薛伟明 于炜婷 王 为 刘袖洞 马小军* 摘要
免疫排斥是细胞移植面临的关键问题。微胶囊的选择透过性膜可对微囊化细胞进行免疫保护，维持其正常的生理状态和功能表达，实现细胞的同种或异种移植，应用前景良好。本文评述了细胞微囊化材料的最新研究进展，如：海藻酸钠、聚赖氨酸、壳聚糖、琼脂等在细胞微囊化中的理化特性与应用；评述了聚电解质络合、界面相转化、共形包衣等细胞微胶囊制备方法。 薛伟明 女，36岁，副教授，博士后，现从事膜分离及生物医学材料研究。
*联系人 E-mail:maxj@dicp.ac.cn |