The New Process for Preparing 5-Dimethylaminomethyl-2-furanmethanol

Liu Fude,  Liu Yan ^a,  Li Baoli ^b,  Duan Yanxin,   Xu Guofeng
( Tianjin University of Technology, Tianjin  300191)
(^a Hebei University of Technology, Tianjin  300130)
(^b Tianjin Univ. Tech. Co. Ltd, Tianjin  300072)

Abstract  5-Dimethylaminomethyl-2-furanmethanol has been synthesized by new process and characterized by IR and ¹H NMR.The advantage of the new process is that with less amount of HAc added and shorter time of reaction, the product yield is 82% which is higher than that of cited process(1) (2). The purity of the product is 98.5%(GC).
Key words  5-Dimethylaminomethyl-2-furanmethanol,  Mannich reaction,  Ranitidine

5-二甲氨基甲基-2-呋喃甲醇合成新工艺

刘福德  刘雁^a  李宝立^b  段艳馨  许国凤
(天津理工学院生物与化学工程学院  天津  300191)
(^a 河北工业大学化学工程学院  天津 300130)
(^b 天大天久科技股份有限公司  天津 300072)

摘要  采用新工艺合成了5-二甲氨基甲基-2-呋喃甲醇，并利用IR及¹H NMR对产品进行了结构表征。新工艺的特点是醋酸用量减少，反应时间缩短，产品收率高达82%，纯度为98.5%(气相色谱法)。
关键词  5-二甲氨基甲基-2-呋喃甲醇  Mannich反应  雷尼替丁

刘福德  男，38，副教授，从事精细化工教学科研工作。
2003-01-15收稿

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