Advances in Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridine Derivatives

Yin Xianhong
(Chemistry Department, Guangxi University for Nationalities, Nanning 530006)

Abstract The main methods of synthesis and aromatization of Hantzsch 1,4-dihydropyridine derivatives was reviewed in this paper. The former included the reactions of ethyl acetoacetate and aromaticaldehyde with ammonia or primary amine, the reactions of 1,3-diketone compounds and aromaticaldehyde with ammonia or primary amine, the reactions of enamine compounds with aromaticaldehyde, the reactions of 1,5-diketone with amine, the reactions of a,b-unsaturated ketone with enamine or ketone and amine. The synthetic technologies included solid-phase synthesis and microwave-assistant synthesis. The latter included photochemical reactions, electrochemical reactions, dehydrogenation reactions, hydrogen transfer reactions.
Key words Hantzsch 1,4-Dihydropyridine, Synthesis, Aromatization