Application of Pressure Reducing Column Chromatography in the Formulation of New Pesticide HNPC-A9835

Liu Aiping1,2 Yu Zhengying1
(1Hunan Institute of Chemical Industry Changsha 410007 2 Central China Normal University Wuchan 430079)

Abstract The application of pressure reducing column chromatography(PRCC) in the formulation of new pesticides has been studied. Using silica gel H for thin-layer chromatography(TLC) as absorbent and petroleum ether and ethyl acetate as mixed washing agent, New pesticide HNPC-A9835 has been separated and purified with the content of 96.72% by PRCC, the method of PRCC is rapid and simple and its result is desirable.
Key words Pressure reducing column chromatography(PRCC), Separation and purification, New pesticide HNPC-A9835, Formulation of new pesticides


减压柱层析在新杀虫剂HNPC-A9835创制中的应用

柳爱平1,2 于正英1
(1湖南化工研究院 长沙 410007 2华中师范大学有机合成研究所 武汉 430079)

摘要 研究了减压柱层析分离纯化方法在新药合成中的应用。利用薄层层析硅胶H为吸附剂，石油醚和乙酸乙酯为混合洗脱剂，通过减压柱层析，分离纯化新型杀虫剂HNPC-A9835，纯度达96.72%。减压柱层析分离纯化方法具有快速、简便的特点，并可达到理想的分离效果。
关键词 减压柱层析 分离纯化 新杀虫剂HNPC-A9835 新药创制

柳爱平 女，36岁，副研究员，博士生，现从事新农药创制研究。
国家“九五”攻关专题(96-A02-03-02-B03)和湖南省自然科学基金重点项目(01JJY1001)
2002-07-11收稿，2003-03-24修回

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