The Surface Modification of the drug-loaded nonparticles

Lu Jian, Chang Jin, Zhao Shuo, Yuan Xubo^*
(Institute of Material Science and Engineering, Institute Nanobiological Technique, Tianjin University, Tianjin 300072)

Abstract This review presents the most recent studies on surface modification of the drug-loaded nano-system.The paper covers the methds of surface modification applied to drug-loaded nanoparticles. The effect of surface modification of drug-loaded nanoparticles on drug release character and drug circulating kinetics are also described. In addition, we presents the mechanism and usage of poly(butyl cyanoacrylate) (PBCA)NP overcoated with polysorbate to facilitate drug penetrating through the blood-brain barrier (BBB).
Key words Drug-loaded nanoparticle, Surface modification, Drug controlled release, Drug circulating kinetics, Blood-brain barrier