Development on Preparation of Drug-Loaded Nanoparticles

Zhao Shuo, Chang Jin,^* Lu Jian, Yuan Xubo
(School of Material Science and Engineering, Tianjin University, Tianjin 300072)

Abstract As effective drug delivery devices, drug-loaded nanoparticles have generated tremendous interest due to their excellent biocompatibility, biodegradability, and subcellular size. Drug-loaded nanoparticles can not only effectively deliver the drug to target site and thus increase the therapeutic benefit, while minimizing side effects, but also can be absorbed by the cells through the tissue matrix. They can penetrate the capillary vessel without causing trauma, and even be able to cross the blood-brain barrier (BBB). They are made to carry a variety of drug classes such as vaccines, peptides proteins and DNA. In this paper the various traditional and novel techniques of preparing various drug loaded polymer nanoparticles are discussed with emphasis on preparing nanoparticles and the influence factor. Also certain issues about the drug load and drug release are covered.
Key words Nanoparticles, Drug delivery, Method of preparation, Controlled release