Synthesis of Propyl p-hydroxybenzoate with FeCl3·6H2O as a catalyst

Wang Mingxing1,2, Song Ximing2, Zhang Shufen1, Yang Jinzong1
(1 The State Key Laboratory of Fine Chemicals, Dalian University of Science and Technology, Dalian 116012)
(2 Deparment of Chemistry, Liaoning University, Shenyang 110036)

Abstract Propyl p-hydroxybenzoate was prepared from p-hydroxybenzoic acid and propanol, in which FeCl3·6H2O was used as a catalyst, propanol as both a reactant and a solvent. The effects of reaction time, the amount of FeCl3·6H2O and reactants on the esterification yield were investigated. Under the optimum reaction conditions of n(propanol)/n(p-hydroxybenzoic acid)=3, n(FeCl3·6H2O)/n(p-hydroxybenzoic acid)=0.06, and reflux time 3h, the product with purity over 98% and yield higher 95% was obtained.
Key words Propyl p-hydroxybenzoate, Ferric chloride, Catalyst, Preperation

　

FeCl3·6H2O催化合成对羟基苯甲酸丙酯

王明星1,2 宋溪明2* 张淑芬1 杨锦宗1
(1大连理工大学精细化工国家重点实验室 大连 116012 2辽宁大学化学科学与工程学院 沈阳 110036)

摘要 以FeCl3·6H2O为催化剂，以既作反应物又作溶剂的丙醇和对羟基苯甲酸为原料，回流脱水直接酯化合成了对羟基苯甲酸丙酯，讨论了该催化酯化的各种影响因素。得到的反应最佳条件为:n(丙醇):n(对羟基苯甲酸)=3:1，n(催化剂):n(对羟基苯甲酸)=0.06:1回流反应3h，该条件下酯化率达到95%以上，酯含量达98%以上。
关键词 对羟基苯甲酸丙酯 三氯化铁 催化剂 合成

王明星 男，34岁，讲师，博士生，现从事有机合成化学、精细化学品化学的教学和科研工作。*联系人
辽宁省优秀青年科技人才培养基金（973007）和大连理工大学精细化工国家重点实验室资助项目
2002-01-05收稿，2002-03-05修回

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