Synthesis of 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine

Jiang Xuliang, Wan Yuhua, Mao Xiaoyuan, Shen Delong
(College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014 )

Abstract 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine was synthesized by two different routes from 5-Amino-3-mercapto-1,2,4-triazole, benzyl chloride and acetylacetone. Reaction was improved with one-step method, and the reaction conditions were optimized. Yield of objective product was over 83%. The structure of the product was proved by means of IR, ¹H NMR spectrum, elemental analysis data.
Key words 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine, 5-Amino-3-mercapto-1,2,4-triazole, Benzylation, Cyclizative condensation, Optimization of reaction condition

5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶的合成

蒋旭亮 王煜华* 毛筱媛 於伟刚 沈德隆
(浙江工业大学化工学院 杭州 310014)

摘要 以5-氨基-3-巯基- 12,4-三唑、氯化苄和乙酰丙酮为原料，分别用先环合和后环合路线合成了5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶，并对后环合路线进行了一步法改进，同时优化了其反应条件，使目标产物的产率达到了83%以上。产品的结构经红外、核磁及元素分析确认。
关键词 5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶, 5-氨基-3-巯基-1,2，4-三唑 苄基化 环化缩合 反应条件优化