Arsenic Trioxide and Carcinoma Cell Apoptosis

Wang Jianhua, Xu Xiaoying, Wang Yuanliang
(Bioengineering College at Chongqing University, Key Laboratory for Biomechanics
and Tissue Engineering under Ministry of Education. Chongqing 400044）

Abstract Arsenic trioxide, an inorganic compound of trivalent arsenic, is highly poisonous after acute exposure and carcinogenic following chronic exposure. Although arsenicals have long been used therapeutically, they have aroused increasing interest recently by the discovery that arsenic trioxide can induce apoptosis in the APL cell and other cancer cells. The article demonstrates the relative concepts of apoptosis and summarizes the effect of arsenic trioxide to the carcinoma, its possible principle included.
Key words Arsenic trioxide, Apoptosis, Carcinoma

王建华 徐小英 王远亮
（重庆大学生物工程学院和生物力学与组织工程教育部重点实验室 重庆 400044）

摘要 三氧化二砷是一种剧毒化合物，长期接触会致癌。作为药物，砷化合物已有很久历史，近期由于其可诱导急性早幼粒白血病细胞和其它癌细胞凋亡而备受关注。文章叙述了细胞凋亡的相关概念，总结了三氧化二砷近年来对癌细胞的凋亡作用以及其可能的机理。
关键词 三氧化二砷 细胞凋亡 癌

王建华 男，39岁 ，副教授，主要从事功能性药物合成、表征与应用研究。
2001-05-13收稿，2001-08-13修回