The Synthesis and Biological Activities of 1,2,4-Triazole-5-Thiones Bearing 2-Chloropyrid-5-Methyl

Li Xinzhi,  Lu Dongfei,  Si Zongxing*
(College of Applied Chemistry China Agricultural University, Beijing 100094)

Abstract Three new triazole were synthesized by the cyclization of 1-aroyl-4-(2-chloropyrid-5-yl)methylthiosemicarbazides 9a～c. All the compounds were identified by elemental analysis and spectral data of IR ¹H NMR ¹³C NMR. Preliminary biological test showed that these compounds exhibit good plant-growth regulative activities on rice.
Key words Synthesis, 1,2,4-Triazolidine-5-thione, Structural characterization, Biological activities

1,2,4-三唑啉-5-硫酮类化合物的合成及生物活性

李新芝   鲁东飞   司宗兴^*
(中国农业大学应用化学学院  北京  100094)

摘要  报道了由1-芳酰基-4-(2-氯吡啶-5-基)甲基氨基硫脲9a～c经关环反应制备了三个新的1,2,4-三唑啉-5-硫酮类化合物, 并通过IR、¹H NMR、¹³C NMR、元素分析确证了上述化合物的结构。初步的生物活性测定表明，化合物对水稻幼苗根的生长表现出较好的生长调节活性。
关键词  合成 1,2,4-三唑啉-5-硫酮 结构表征 生物活性

李新芝 男，25岁，硕士生，主要从事有机合成工作，*联系人
国家“九五”攻关项目“新农药的研究与开发”(97-563-02-06)
2001-07-16收稿，2001-09-06修回