Recent developments in solid-phase organic synthesis Yao Wei，Zeng Longmei (School of Chemistry and Chemical Engineering Zhongshan University, Guangzhou 510275) Abstract In the recent years, the solid-phase organic synthesis (SPOS) has been making progress quickly. Many kinds of reaction, such as nucleophilic and electrophilic substitutions, condensations, cycloadditions, oxidation and reduction reactions etc, can be carried out on the solid-phase reaction condition. Organic chemists have been paid more attention to SPOS owing to the easy separation and purification of the products as well as the low environment pollution. Recently, the applications of SPOS are developing rapidly. In this paper the recent developments on the solid-phase organic synthesis are reviewed. Key words Solid-phase organic synthesis, Compound library, Reaction 固相有机合成反应的新进展 姚 卫 曾陇梅* (中山大学化学与化学工程学院 广州 510275) 摘要 固相有机合成(SPOS)近年来有长足的发展，许多类型的取代(亲核/亲电)、缩合、环加成、氧化和还原等反应都能在固相反应条件下进行。固相有机反应由于其反应产物分离、提纯方法简单，环境污染少而备受化学家重视。目前这一方法的应用范围正在不断扩大。本文主要综述近期固相有机合成方面的新进展。 关键词 固相有机合成 化合物库 反应 姚卫 男，24岁，硕士生，现从事药物及其先导化合物的合成研究。*联系人 E-mail:ceszlm@zsu.edu.cn 广东省自然科学基金项目(970154) 2001-07-016收稿，2001-11-12 修回 (PDF全文下载c02029)