Development on Preparation of Drug-Loaded Nanoparticles Zhao Shuo, Chang Jin,* Lu Jian, Yuan Xubo (School of Material Science and Engineering, Tianjin University, Tianjin 300072) Abstract As effective drug delivery devices, drug-loaded nanoparticles have generated tremendous interest due to their excellent biocompatibility, biodegradability, and subcellular size. Drug-loaded nanoparticles can not only effectively deliver the drug to target site and thus increase the therapeutic benefit, while minimizing side effects, but also can be absorbed by the cells through the tissue matrix. They can penetrate the capillary vessel without causing trauma, and even be able to cross the blood-brain barrier (BBB). They are made to carry a variety of drug classes such as vaccines, peptides proteins and DNA. In this paper the various traditional and novel techniques of preparing various drug loaded polymer nanoparticles are discussed with emphasis on preparing nanoparticles and the influence factor. Also certain issues about the drug load and drug release are covered. Key words Nanoparticles, Drug delivery, Method of preparation, Controlled release 载药纳米微粒制备技术 赵 硕 常 津* 卢 剑 原续波 (天津大学材料科学与工程学院 天津 300072) 摘要 载药纳米微粒作为近年来新型的药物投递载体，由于其良好的生物相容性、超微小的粒径、良好的体内分布而受到日益广泛的关注。作为包载疫苗、多肽、蛋白和基因等大分子药物的载体，载药纳米微粒不仅可以增强药物的稳定性、增强疗效、降低毒副作用，由于其超微小的粒径可以有效地穿越组织间隙，可通过人体的毛细血管甚至血脑屏障被细胞吸收，从而更有效地对药物实行靶向和控制释放。本文重点论述了载药纳米微粒系统制备方法的研究进展，并对其中的影响因素、药物的包载和控制释放进行了讨论；同时对于载药纳米微粒的发展做出展望。 关键词 纳米粒子 药物载体 制备方法 控制释放 赵硕 男，24岁，硕士生，现从事载药纳米微粒系统研究。 *联系人 E-mail:jinchang4@hotmail.com 国家科委基础研究快速反应支持项目(200151) 2002-04-18收稿，2002-07-08修回 (PDF全文下载c02093)