Synthesis of 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine Jiang Xuliang, Wan Yuhua, Mao Xiaoyuan, Shen Delong (College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014 ) Abstract 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine was synthesized by two different routes from 5-Amino-3-mercapto-1,2,4-triazole, benzyl chloride and acetylacetone. Reaction was improved with one-step method, and the reaction conditions were optimized. Yield of objective product was over 83%. The structure of the product was proved by means of IR, 1H NMR spectrum, elemental analysis data. Key words 2-Benzylthio-5,7-dimethyl-1,2,4-triazole[1,5-a]pyrimidine, 5-Amino-3-mercapto-1,2,4-triazole, Benzylation, Cyclizative condensation, Optimization of reaction condition 5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶的合成 蒋旭亮 王煜华* 毛筱媛 於伟刚 沈德隆 (浙江工业大学化工学院 杭州 310014) 摘要 以5-氨基-3-巯基- 12,4-三唑、氯化苄和乙酰丙酮为原料，分别用先环合和后环合路线合成了5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶，并对后环合路线进行了一步法改进，同时优化了其反应条件，使目标产物的产率达到了83%以上。产品的结构经红外、核磁及元素分析确认。 关键词 5,7-二甲基-2-苄硫基-1,2,4-三唑[1,5-a]嘧啶, 5-氨基-3-巯基-1,2，4-三唑 苄基化 环化缩合 反应条件优化 蒋旭亮 男，26岁，硕士生，现从事有机杂环及农药的合成研究。E-mail:Xuliangjiang@21cn.com *联系人 浙江省自然科学基金资助项目(301266) 2001-09-17收稿，2002-02-05修回 (PDF全文下载c02055)