The New Progress in the Studies on Antibacterial Properties of Schiff Bases and its Metal Complexes Wang Jianhua, Lei Wen#, Wang Yuanliang (College of Bioengineering, #College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044) Abstract Schiff bases and its transition metal complexes have significant antiviral and antibacterial activities. In order to screen the high-activity antibiotic drugs with low toxicity, a large number of Schiff bases and its metal complexes have been synthesized, and the bioactivity screening of these ligands and complexes were done against different bacterial species. The research progress of antimicrobial activities of some kinds of Schiff base and its metal complexes are presented. The problems in the study on Schiff bases' antibacterial activities and the way of solutions are summarized and the prospects of the research methods are described. Key words Schiff bases, Metal complexes, Antibacterial properties Schiff碱及其金属配合物的抑菌活性 王建华 雷 文# 王远亮 (重庆大学生物工程学院 #重庆大学化学化工学院 重庆 400044) 摘要 Schiff碱及其过渡金属配合物具有独特的抗病毒、抑制细菌生长等生物活性。为筛选高效低毒的抗菌剂，人们合成了大量不同类型的Schiff碱及其金属配合物，并对不同菌株的抑制作用进行了研究；本文介绍了近年来国内外Schiff碱及其金属配合物的抑菌活性研究，总结了Schiff碱抑菌活性研究中所存在的问题及解决的方法，并就其研究方法进行了展望。 关键词 Schiff碱 金属配合物 抑菌活性 王建华 男，39岁，副教授，从事生物无机化学的研究。E-mail:cquwjh@163.net 国家自然科学基金项目(19872080) 2001-04-02收稿，2001-12-21修回 (PDF全文下载c02035)