Carbonylation of Methyloxirane to Methyl b-Hydroxylbutyrate by Cobalt Carbonyl Catalysts

Abstract Methyloxirane was converted with carbon monoxide and methanol to methyl b-hydroxybutyrate in the presence of Co₂(CO)₈/3-hydroxypyridine catalyst system. The salts compound, which may be inorganic or organic has accelerating effect on the hydroesterification of methyloxirane. Under optimum conditions, T=80°Cand p=7.0MPa for 6h, sodium acetate as co-catalyst employed, a 93% conversion of methyloxirane can be obtained with a selectivity of 97% methylb-hydroxylbutyrate. In addition, the effect of reaction of methyloxirane in the presence N-compound ligands and solvents was examined.
Key words Carbonylation, Cobalt carbonyl catalyst, Oxirane, Hydroxylbutyrate

钴催化羰化环氧丙烷制β-羟基丁酸酯的研究

陈 静    付宏祥   童 进
（中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室 兰州 730000）

摘要 在Co₂(CO)₈/3-羟基吡啶催化体系中，加入盐助剂醋酸钠作助催化剂，环氧丙烷与CO和甲醇发生羰化氢酯基化反应。在反应温度80℃、压力7.0 MPa、时间为6h时，生成了一种羰基化产物β-羟基丁酸酯，其收率和选择性分别达到93%和97%以上。
关键词 钴催化  羰基化   环氧丙烷  羧酸酯

陈 静 女，37岁，副研究员，现从事均相催化和羰基合成方面的研究工作。
2000-12-28收稿，2001-02-28修回

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