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| 金属有机框架复合材料修饰电化学传感器检测对乙酰氨基酚的研究进展 |
| Research Progress of MOFs-Based Composites Modified Electrochemical Sensors for Acetaminophen Detection |
| 投稿时间：2026-03-24 修订日期：2026-05-07 |
| DOI： |
| 中文关键词: 金属有机框架 电化学传感器 对乙酰氨基酚 快速检测 |
| 英文关键词:MOFs Electrochemical sensors Acetaminophen Rapid detection |
| 基金项目:国家自然科学基金项目（82574099） |
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| 摘要点击次数: 55 |
| 全文下载次数: 0 |
| 中文摘要: |
| 对乙酰氨基酚(APAP)是临床应用最广的解热镇痛药之一,在生产、使用过程中会随废水排放到环境水体中,造成环境污染的同时也存在食品非法添加等安全隐患,因此开发快速、精准的检测技术具有重要价值。传统的检测方法如高效液相色谱、紫外分光光度法、毛细管电泳法等虽然具有较高的检测灵敏度和准确性,但存在操作繁琐、耗时长且仪器成本高等局限,难以满足现场快速检测需求。相比之下,电化学传感技术凭借响应快、成本低、易微型化等优势,成为理想的替代方案。金属有机框架(MOFs)因具备高比表面积、可调多孔结构和丰富的活性位点,是构建高性能电化学传感器的优质材料。本文系统综述了MOFs基复合材料在APAP电化学检测中的应用进展,深入分析了其合成方法与设计思路,并总结了复合策略在提升传感器电催化活性、灵敏度和选择性方面的显著优势。本文还探讨了该领域当前面临的主要挑战及未来发展趋势,并为新型传感材料的设计与实际应用提供理论指导。 |
| 英文摘要: |
| Acetaminophen (APAP) is one of the most widely used antipyretic and analgesic drugs in clinical practice. During its production and application, APAP is discharged into environmental water bodies with wastewater, which not only causes environmental pollution but also poses potential safety hazards such as illegal adulteration in food. Therefore, the development of rapid and accurate detection technologies for APAP is of great significance. Traditional detection methods, including high-performance liquid chromatography (HPLC), ultraviolet spectrophotometry and capillary electrophoresis, have high detection sensitivity and accuracy. However, they are limited by cumbersome operation, long time consumption and high instrument cost, which make it difficult to meet the demand for on-site rapid detection. In contrast, electrochemical sensing technology has become an ideal alternative due to its advantages of fast response, low cost and easy miniaturization. Metal-organic frameworks (MOFs), with high specific surface area, tunable porous structure and abundant active sites, are high-quality materials for constructing high-performance electrochemical sensors. This paper systematically reviews the research progress in the application of MOFs-based composites for the electrochemical detection of APAP, conducts an in-depth analysis of their synthesis methods and design rationales, and summarizes the remarkable advantages of composite strategies in enhancing the electrocatalytic activity, sensitivity and selectivity of sensors. Furthermore, this paper discusses the main current challenges and future development trends in this field, so as to provide theoretical guidance for the design and practical application of novel sensing materials. |
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