| 段明月,孙昱恒,徐雪园,宋佳硕,孙先宇,何卫刚.化学通报,2026,89(7):841-848. |
| Tubingensins A和B全合成研究进展 |
| Research Progress on the Total Synthesis of Tubingensins A and B |
| 投稿时间：2026-03-01 修订日期：2026-04-27 |
| DOI： |
| 中文关键词: Tubingensin A Tubingensin B 吲哚二萜 全合成 |
| 英文关键词:Tubingensin A, Tubingensin B, indole diterpenoid, total synthesis |
| 基金项目:国家自然科学基金项目(22401019)和江苏省大学生创新训练计划项目(S202510333008)资助 |
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| 中文摘要: |
| Tubingensins A和B是从曲霉菌属真菌(Aspergillus tubingensis)中分离得到的吲哚二萜类生物碱,这两个天然产物具有复杂的多环结构,并展现出明确的杀虫、抗病毒和抗肿瘤活性。Tubingensins A和B因其富有挑战的化学结构以及丰富的药理活性成为了有机化学全合成领域的重要研究对象,本文综述了目前Tubingensins A和B的全合成研究进展。 |
| 英文摘要: |
| Tubingensins A and B are indole diterpenoid alkaloids isolated from the fungus Aspergillus tubingensis. These natural products possess intricate polycyclic structures and demonstrate well-defined insecticidal, antiviral, and antitumor activities. Due to their synthetically challenging chemical architectures and diverse pharmacological profiles, Tubingensins A and B have emerged as important targets in the field of organic total synthesis. This review summarizes the current progress on the total synthesis of Tubingensins A and B. |
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