| 刘家瑞#,王浩然#,张茹佳,吴钰,黄柯宁,陈浩宇,支德福.化学通报,2026,89(7):794-804. |
| 基于复合型微针的基因与药物递送研究进展 |
| Advances in Composite Microneedle-Based Delivery Systems for Genes and Drugs |
| 投稿时间：2025-12-10 修订日期：2026-03-24 |
| DOI： |
| 中文关键词: 复合型微针 经皮递送 基因治疗 药物治疗 协同治疗 |
| 英文关键词:Composite microneedles Transdermal delivery Gene therapy Drug therapy combined therapy |
| 基金项目:国家自然科学基金项目(21503035/U23A20488)、辽宁省科技计划联合计划项目(2023JH2/101700075)、大连市高层次人才支持计划项目(202312026/2023RJ005)和大学生创新创业训练计划项目(202512026016)资助 |
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| 中文摘要: |
| 复合型微针作为一种融合多材料、多结构及多功能单元的经皮给药平台，在药物与基因递送领域展现出巨大潜力。通过聚合物、水凝胶及复合材料的协同设计，微针可实现药物的稳定保护、可控释放与靶向递送。在基因、蛋白质以及药物递送方面展现除优异效果并且可以实现葡萄糖响应释药、联合免疫治疗及高效透皮吸收。总体而言，复合型微针可在无痛、可控的条件下实现多类药物的精准给药，为个体化治疗提供新策略。本综述系统地总结了复合型微针的最新研究进展，强调了其在疾病治疗中的巨大潜力，同时评估了临床应用中的转化挑战。 |
| 英文摘要: |
| Composite microneedles (CMs) emerging as represent an advanced transdermal drug delivery platform, characterized by the sophisticated integration of multiple materials, structural designs, and functional components across multi-disciplinary domains. The rational synergistic engineering of polymers, hydrogels, and composite matrices is pivotal, enabling effective and stable therapeutic payload protection, spatiotemporally controlled release, and targeted delivery. CMs have consistently demonstrated high efficacy for a diverse range of therapeutics, including genes, proteins, and small-molecule drugs as well as natural products. Notably, stimuli-responsive and multi-modal advanced functionalities, such as glucose-responsive insulin release, integrated immunotherapy with chemotherapeutics, and enhanced transdermal absorption, have been successfully implemented. By facilitating precise minimally invasive, tunable, and painless administration, composite microneedles offer a clinically translatable robust foundation for personalized medicine. This review systematically summarizes key breakthroughs and underlying mechanisms of recent advances in CM technologies, highlights their transformative potential in treating various diseases, and critically assesses the translational challenges currently impeding clinical implementation. |
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