| 杨甜星*,宫俊琰,张秀莲,张 萍,陶传洲.化学通报,2026,89(4):457-461,440. |
| 铜催化氢硅烷对喹啉-2-酮的选择性还原 |
| Copper-Catalyzed Selective Reduction of Quinolin-2-ones with Hydrosilane |
| 投稿时间：2025-11-30 修订日期：2026-01-10 |
| DOI： |
| 中文关键词: 铜催化 喹啉-2-酮 3,4-二氢喹啉-2-酮 氢硅烷 |
| 英文关键词:Copper-catalysis Quinolin-2-one 3,4-Dihydroquinolin-2-one Hydrosilane |
| 基金项目:江苏省可见光催化材料工程研究中心(连云港职业技术学院)开放基金项目(JECVCM202202)、连云港市科技计划项目(JCYJ2402)和江苏省研究生实践创新计划项目(SJCX24_2100)资助 |
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| 中文摘要: |
| 3,4-二氢喹啉-2-酮是一类重要的含氮杂环化合物，广泛存在于天然产物和药物分子中，在海洋防污剂中也具有潜在应用价值。本文开发了一种廉价铜催化体系，以醋酸铜/膦配体与氢硅烷生成铜氢物种，高选择性还原喹啉-2-酮，合成了系列3,4-二氢喹啉-2-酮类化合物。该方法条件温和，底物适用性广，产率高，且催化剂和配体均为商业可得。本研究为3,4-二氢喹啉-2-酮类化合物的绿色高效合成提供了新思路，在精细化工等领域具有重要意义。 |
| 英文摘要: |
| 3,4-Dihydroquinolin-2-ones are an important class of nitrogen-containing heterocyclic compounds widely found in natural products and drug molecules, and also possess potential applications as marine antifouling agents. This study developed a cost-effective copper-catalyzed system, where copper hydride species generated in situ from copper acetate/phosphine ligand and hydrosilane were used to selectively reduce quinolin-2-ones, synthesizing a series of 3,4-dihydroquinolin-2-one derivatives. This method features mild conditions, broad substrate compatibility, high yields, and commercially available catalysts and ligands. The research provides a new approach for the green and efficient synthesis of 3,4-dihydroquinolin-2-one compounds and holds significant value for applications in fine chemicals and related fields. |
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